Human butyrylcholinesterase polymorphism: Molecular modeling
نویسندگان
چکیده
منابع مشابه
Human butyrylcholinesterase polymorphism: Molecular modeling.
BACKGROUND Prolonged apnoea following injection of ester-containing myoralaxants was first described in 1953. Because a large part of administered succinylcholine is shortly hydrolyzed by plasma butyrylcholinesterase (BChE) under normal conditions, prolonged apnoea was attributed to deficiency in BChE. It was found that BChE deficiency was due to genetic variations. Human BChE gene shows a larg...
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Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) catalyze the hydrolysis of the neurotransmitter acetylcholine and, thereby, function as coregulators of cholinergic neurotransmission. For both enzymes, hydrolysis takes place near the bottom of a 20 Å deep active site gorge. A number of amino acid residues within the gorge have been identified as important in facilitating efficient ...
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ژورنال
عنوان ژورنال: International Journal of Risk & Safety in Medicine
سال: 2015
ISSN: 0924-6479,1878-6847
DOI: 10.3233/jrs-150699